An independent review panel says substandard science has crippled a federal agency's seven-year effort to document possible links between industrial pollution and health problems in the Great Lakes region. The Institute of Medicine says drafts of a report still under development by the federal Centers for Disease Control were deeply flawed. The institute says the shortcomings include use of questionable data and conclusions that weren't backed by sufficient evidence. Versions of the report made public earlier this year suggest pollution is causing health problems such as cancer and premature births. The pollution includes toxins such as PCBs and mercury. Chicago, Milwaukee, Detroit and Cleveland are listed among the cities with areas of concern.