CHICAGO (AP) -- Jay Cutler threw for 333 yards and two touchdowns, Michael Bush added a pair of scoring runs and the Chicago Bears spoiled Andrew Luck's debut in beating the Indianapolis Colts 41-21 Sunday.
Brandon Marshall had nine catches for 119 yards and a touchdown in his first game since being reunited with Cutler. Matt Forte ran for 80 yards and a score, and also had 40 yards receiving.
Luck finished his first NFL game 23 of 45 for 309 yards with a 4-yard touchdown pass to Donnie Avery early in the fourth quarter. He also was intercepted three times -- twice by Tim Jennings -- in an up-and-down debut for a quarterback with huge shoes to fill.
The No. 1 pick in the draft is stepping in for four-time NFL MVP Peyton Manning, who missed last season with a neck injury and now plays for Denver.
Reggie Wayne caught nine passes for 135 yards. But it was a familiar result for a team with new management and a new coach in Chuck Pagano after winning just two games last season.