Dominique Canty scored 12 for Chicago. Candice Dupree, Chasity Melvin and Armintie Price each added 11.
Tamika Whitmore scored a season-high 26 for the Fever, who lost their second straight after winning their previous six.
Indiana was playing without All-Star forward Tamika Catchings, who suffered a partial tear of her left plantar fascia in yesterday's 89-to-80 loss to Detroit.
Indiana came into tonight's game tied with the Shock for first place in the Eastern Conference.