Rob Mackowiak, Jim Thome and Paul Konerko homered during a five-run third inning as the Chicago White Sox doubled up Minnesota 6-3.
Javier Vazquez won his third straight start allowing eight hits over eight innings including Justin Morneau's 24th homer.
Vazquez is 6-5 after his second straight complete game and 22nd of his career. He walked no one and fanned eight including the last two batters of the game.
All three White Sox homers came off Carlos Silva, who fell to 6-10.