Lofton started the rally off loser Bob Howry with a leadoff pinch-hit single.
Texas took a 3-to-0 lead in the second with back to back home runs by Victor Diaz and Adam Melhuse.
Cubs starter Ted Lilly may have deserved a better fate as he struck out ten and walked just one in seven innings of work. The loss by Howry is his fourth in seven decisions. The win was picked up by Eric Gagne, who is 2-and-0.