Astros starter Chris Sampson pitched five scoreless innings and Luke Scott had a two-run double in a three-run first. Carlos Lee added an r-b-i single.
Cubs shortstop Cesar Izturis committed three errors as Chicago dropped to 3-and-5.
Jason Marquis took the loss in his first home start for the Cubs. He's 1-and-4 at Wrigley Field.
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or firstname.lastname@example.org.