Angels left-hander Joe Saunders allowed eight hits and seven runs, six earned, in six innings. Cubs starter Jason Marquis gave up seven hits and four runs in four-and-a-third innings. Vladimir Guerrero hit a solo homer and Garret Anderson added a two-run shot off Marquis, a free-agent acquisition for Chicago.
Guerrero, Gary Matthews Junior and Shea Hillenbrand each had two hits for the Angels.
Bob Howry and Scott Eyre closed out the game with hitless innings for the Cubs.