Khalil Greene hit a three-run home run to help Shawn Estes earn his first victory since 2005 with the San Diego Padres' 4-3 victory over the Chicago Cubs on Tuesday night.

Estes pitched 5 1-3 innings and the Padres' bullpen secured the win with 3 2-3 innings of hitless relief. Trevor Hoffman pitched a scoreless ninth for his seventh save in nine chances. It was the 531st save of his career.

Alfonso Soriano led off the first inning with a home run and Reed Johnson had a two-run double for the Cubs.