It comes in response to concerns that the antibiotics lessen the drugs' effectiveness for humans.
Environmental and other groups have been consulting with the fast-food giant on the changes for nearly a year.
McDonald's is prohibiting its direct suppliers, which supply 70 percent of its poultry from using medically important antibiotics to promote growth in food animals after 2004.
McDonald's says the new policy also will be encouraged for indirect suppliers of beef and pork.
The company says incentives will be offered for complying with the policy.
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