Republicans in New York say maybe she'll do better creating jobs in her home state than she's done in her adopted state.
New York GOP leader Stephen Minarik says Clinton "hasn't done anything" to create jobs in New York since being elected to the Senate.
The former first lady grew up in Illinois and is speaking at the Economic Club of Chicago.
Clinton adviser Howard Wolfson says New York Republicans tried to use the "carpetbagger" issue against her in the 2000 election and Clinton still won by a wide margin.
Clinton had pledged to bring jobs to upstate New York, but instead the region has lost jobs, a situation she blames on the Bush administration's economic policies.