Nevada Democrat and Senate Minority Leader Harry Reid will lead the group, which will review security, economic and political issues in the region.
The senators will meet with senior foreign officials, U.S. Foreign Service and military personnel.
Also going on the trip will be Senators Bob Bennett of Utah, Lamar Alexander of Tennessee, Ken Salazar of Colorado, Barbara Boxer of California and Patty Murray of Washington.
The delegation will be traveling through next week.
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