Winnebago County police say a red minivan driven by a female was traveling southbound on Springfield Avenue when she swerved into the right side of the road and hit a northbound blue Jeep.
The crash occurred just north of the bridge on Springfield, between Kilburn and Safford Roads.
The minivan driver was ejected and found in the trees near the road. She was taken to Rockford Memorial Hospital where she later died.
Rockford fire officials extricated the Jeep driver and that person was also taken to Rockford Memorial Hospital with serious injuries.
The names have not been released yet. The Winnebago County Sheriff's Department says the weather may have been the cause of the accident. The incident remains under investigation.